3,6,8-Tribromo-7-ethylamino-4-methyl-2H-chromen-2-one
نویسندگان
چکیده
In the title mol-ecule, C(12)H(10)Br(3)NO(2), the 2H-chromen ring is essentially planar (r.m.s. deviation = 0.022 Å) with the ethyl-amino group oriented at 13.9 (5)° with respect to the ring. The mol-ecular structure is stabilized by intra-molecular N-H⋯Br and C-H⋯Br interactions.
منابع مشابه
Efficacy of 4-methyl-7-hydroxy coumarin derivatives against vectors Aedes aegypti and Culex quinquefasciatus.
4-Methyl-7-hydroxy coumarin is considered as a lead molecule as a biopesticide. Its mono bromo and tribromo derivatives were synthesized. Two more derivatives were synthesized by acylation. Compound 1 (3,6,8-tribromo-7-hydroxy-4-methyl-chromen-2-one) was found to be the most potent against IVth instar larvae of C. quinquefasciatus and A. aegypti the LC50 being 1.49 and 2.23 ppm respectively. It...
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In title compound, C(12)H(11)Br(2)NO(2), the coumarin ring system is almost planar, the two rings being inclined to one another by 1.40 (15)°. There are two short intra-molecular inter-actions (N-H⋯Br and C-H⋯Br) involving the Br atoms. In the crystal, mol-ecules stack along the a-axis direction via π-π inter-actions; the centroid-centroid distances vary from 3.6484 (19) to 3.7942 (19) Å.
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BACKGROUND Coumarin and their derivatives are important and useful compounds with diverse pharmacological properties. In the present study, we evaluated the in vitro cytotoxic activity of new acetoxycoumarin derivatives: 4-(7-methoxy-4-methyl-2-oxo-2H-chromen-3-yl)phenyl acetate (1), 4-(1-methyl-3-oxo-3H-benzo[f]chromen-2-yl)phenyl acetate (2), 4-(6-propionamido-4-methyl-2-oxo-2H-chromen-3-yl) ...
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عنوان ژورنال:
دوره 68 شماره
صفحات -
تاریخ انتشار 2012